When you feel a rumble in your stomach, other than trying to decide what you want to eat, you probably don’t put too much thought into eating; well, that is, unless you are watching your weight, of course. But have you ever stopped to think about what happens after you chew and swallow your food? You digest it, of course! But how does digestion happen?
Digestion, of course, refers to the breakdown of food into smaller pieces, and then those pieces are absorbed into your bloodstream to nourish your body, and anything that your body can’t use is excreted. The breakdown of food is a natural process, and digestive enzymes play a massive part. When you eat, digestive enzymes, which are substances, are secreted by your salivary glands and the cells that line the organs that the gastrointestinal tract comprises, the stomach, the pancreas, and the small intestine. Digestive enzymes break down food by splitting up the large, complex molecules that the carbs, proteins, and fats that food is made of into smaller molecules, which allows the nutrients that are locked in the food to be easily absorbed into your blood. Once those nutrients are in the bloodstream, they are then transported throughout the rest of your body.
Digestive enzymes are vital, but some people don’t have the right balance of these essential substances, and an imbalance can result in digestion issues; bloating, digestive upset, indigestion, and in severe cases, immune dysfunction. Fortunately, there’s a way to resolve this imbalance. How? By taking a digestive enzyme supplement.
If you suffer from digestive upset regularly, you may benefit from taking a digestive enzyme supplement. A good supplement can nourish your body with these crucial enzymes, which will, in turn, support your digestion in several ways. However, you need to ensure that you’re taking a suitable digestive enzyme to reap these benefits. Like other types of supplements, there are so many digestive enzymes on the market, so trying to determine which one will offer you the help you’re seeking can seem like a difficult task.
To find a good digestive enzyme supplement, you need to do your due diligence and research, but we’ve taken the liberty of doing that research for you. Our editorial team has scoured the internet, assessing the many other digestive enzymes. After reading through the ingredients, the benefits provided, and customer reviews, we have narrowed down the options to what we believe are the best supplements currently on the market.
The Best Digestive Enzymes for 2022
The results of our research have determined that the following are the best digestive enzymes currently on the market:
- 1MD Enzyme MD Broad Spectrum Digestive Support
- EnzyBurn Formula with Makzyme-Pro
- Live Conscious Broad Spectrum Digest Well
- Bioptimizers MassZymes
- BiOpimizers HCL Breakthrough
- Digestech Full-Spectrum Digestive Enzymes by Onnit
- Total Gut Health Supplement Packets by Onnit
- Enzyme 17 Essential Digestive Enzymes by Organixx
- Digestive Enzyme Ultra Blend by NSP Nutrition
- Vial Plan Active Enzymes
- Digestive Health Source Digestive Enzyme Renewal
- Full Spectrum Complete Enzymes by Amy Myers, MD
- AlphaZym Plus Dietary Supplement
- Digest Gold + Probiotics by EnzyMedica
- Synogut Dietary Supplement
- Digestive Enzymes with Betaine HCL and Pepsin by Gut Garden
- Thorne Bio-Gest Digestive Enzymes
- VeganZyme Advanced Enzyme Blend by Global Healing
Now that you have had a sneak peek at our top picks for the best digestive enzymes in 2022 let’s take a closer look at each one. Below, you’ll find a more detailed overview of each product on our list.
1MD Enzyme MD
A broad-spectrum supplement specially formulated to support digestive health, 1MD Enzyme MD aims to minimize discomfort and gas and bloating that often occurs after eating. This formula comprises a collection of 18 plant-based digestive enzymes, complete with probiotics; as such, it’s one of the most diverse options on our list.
An acclaimed board-certified gastroenterologist developed enzyme MD as a way to relieve the digestive worries out of eating so that you can enjoy peace of mind knowing that your digestive health is being adequately supported. Other digestive enzyme supplements are probiotics found in yogurts. Enzyme MD uses a different approach: it uses S. boulardii to get rid of toxins and gasses.
With excellent customer reviews and affordably priced, it’s easy to see why Enzyme MD tops our list of the best digestive supplements for 2022.
Developed on research, what the manufacturer calls a “forgotten population of island dwellers,” many of whom are centurions, EnzyBurn is an excellent digestive enzyme supplement.
As per the developers of this supplement, the inhabitants of this secluded island eat local foods that contain unique enzymes. The makers included this enzyme in their supplement and purport that by taking it regularly, you will encourage your body to produce a thinning substance that has miraculous capabilities while also burning off up to 12 pounds of fat almost immediately.
Suppose you’re looking for a digestive enzyme centered on the use of ancient medicines. In that case, EnzyBurn may be an excellent option for you to consider. While some of the benefits that it’s advertised to offer to seem a bit exaggerated, like substantial weight loss without diet or exercise, EnzyBurn certainly can help support your weight loss goals. It’s absolutely a high-quality digestive enzyme supplement.
Live Conscious Broad Spectrum DigestWell
A digestive health supplement that utilizes plant-based enzymes to aid with the absorption of nutrients, Live Conscious Broad Spectrum DigestWell is an excellent option. It’s classified as broad-spectrum because it’s comprised of a total of 10 digestive enzymes that quickly kick into action to support digestion in a multitude of ways.
Not only does DigestWell contain premium-quality digestive enzymes, but it is also comprises a mixture of natural foods that are known to contain high levels of digestive enzymes, including ginger, pineapple, and papaya. Made in the USA, tested and approved by a reputable third-party, backed by a 365-day money-back guarantee, and very affordably priced, Live Conscious Broad Spectrum DigestWell is worth trying.
Next on our list of the best digestive health supplements is MassZymes by BiOptimizers. It’s one of the most prevalent digestive enzymes supplements sold on the internet, and it’s backed by plenty of excellent user reviews. It comprises full-spectrum digestive enzymes, allowing optimal nutrition absorption while improving digestion and performance. This supplement is purported to boost the body’s absorption of essential amino acids and vitamins.
According to the manufacturer, this supplement will aid digestion and nutrient absorption. Still, it will also help improve gut health, boost energy levels, enhance cognitive health, improve mental clarity, and sharpen focus. It’s said to improve muscle recovery, too! With each serving of MassZymes by BiOptimizers, you’ll get a hefty dose of protein: 100,000 units!
If you’ve taken protein supplements in the past and they lead to digestive upset, then MassZymes may be the right option for you. Some users take this supplement as part of their bodybuilding stack, while others encourage their bodies to digest protein. No matter your objective, with MassZymes by BiOptimizers, you can enjoy notable benefits.
BiOptimizers HCL Breakthrough
The second product from BiOptimizers on our list, HCL Breakthrough, is another excellent digestive enzyme supplement. Many users combine it with MassZymes, as the two supplements work together to provide profound digestive health benefits.
HCL Breakthrough comprises digestive enzymes that boost the body’s absorption of minerals, vitamin B12, and amino acids. These factors mean that your digestion and gut health will improve, and you’ll also support detoxification. Some users take this supplement to alleviate their bloating, belching, gas, indigestion, and general stomach upset, while others take it to improve their muscle growth and exercise recovery. Regardless of the reason, you plan on taking it, with HCL Breakthrough, you can see a notable improvement in your health.
Onnit Digestech Full Spectrum Digestive Enzymes
Another full-spectrum digestive enzyme supplement, DigesTech by Onnit, improves digestion and overall health and well-being while supporting weight loss and muscle recovery. It’s comprised of some of the highest quality and enzymes that have been proven to support digestive health. These enzymes include the following:
- Protease, which aids in the digestion of protein
- Amylase, which helps digest carbs
- Lipase, which supports the digestion of fats
In addition to these proven digestive enzymes, DigesTech is also comprised of a collection of 12 high-quality natural ingredients, including:
- Ginger root extract
- Fennel seed power
And those are just some of the additional digestive aids. If you’re looking for a supplement that can help support your digestion from various angles, then DigesTech by Onnit may be the right choice for you.
Onnit Total Gut Health
Another option from Onnit, Total Gut Health, is a digestive health enzyme supplement specially formulated to support the balance of healthy flora in the gut, leading to optimal digestion. A large body of research has revealed that healthy gut flora is vital for weight loss, strong immunity, and improving overall health and well-being.
The manufacturer purports that Total Gut Health offers the best results of all digestive enzyme supplements on our list. Not only does it promote the balance of healthy flora in the gut, effectively break down food, and improve the absorption of essential nutrients, but it also supports the digestion of primary macronutrients, and those are just some of the benefits that it’s said to offer. Onnit is one of the most trusted supplement manufacturers on the market, and Total Gut Health is a testament to its reputation. Composed of ingredients that are proven to provide a wealth of benefits, as well as a diverse matrix of digestion, Total Gut Health is one of the best digestive enzyme supplements currently on the market.
Organixx Enzyme 17
Enzyme 17 by Organixx is a full-spectrum supplement comprising 17 enzymes, more than most of the supplements featured on our list. This increased number of enzymes helps boost protein, fat, and carbohydrate metabolism.
Formulated by Dr. Melissa Gallagher, a naturopath, it’s said that Enzyme 17 is designed to target protein deficiencies. It’s also said to boost the body’s use of that protein by nourishing you with a tri-phase protease matrix. In addition to these benefits, Enzyme 17 has one of the most potent dosages on our list of supplements. Examples of these dosages include 12 ENDO-PG of pectinase, 3,000,000 FCCPU of bromelain, and 22,500 DU of amylase. With such a great ingredient profile, combined with a long list of positive reviews, Enzyme 17 is an option that you may want to consider.
NSP Nutrition Digestive Enzyme Ultra Blend
Next up is Digestive Enzyme Ultra Blend by NSP Nutrition. A combination of multiple digestive enzymes that have been proven to boost the digestion of proteins, increase energy levels, enhance fat burning, and even improve sleep, this supplement is highly regarded by so many users.
According to the manufacturer, Digestive Enzyme Ultra Blend offers the benefits mentioned above and helps to slow down the impact of aging. It can do this by boosting the absorption of nutrients that combat the effects of aging. Like other supplements featured on our list, Digestive Enzymes by NSP Nutrition primarily focuses on those interested in using more protein to build more muscle. As if these benefits weren’t enough, this supplement is also affordably priced and backed by a 30-day manufacturer guarantee.
Vital Plan Active Enzymes
Vital Plan is another highly respected supplement manufacturer, and Active Enzymes lives up to their reputation. Composed of a unique blend of digestive enzymes sourced from plants and proven to support the health and function of the gastrointestinal tract, this supplement has received excellent reviews from users.
Created by Dr. Bill Rawls, a medical doctor, this formula is supported by science. In addition to the high-quality digestive enzymes, it contains, Active Enzymes also feature fennel and cardamom, which provide an extra boost to your digestive health.
With each serving, you’ll receive a total of 15 natural, plant-based digestive enzymes when you take Active Enzymes by Vital Plan. Suppose you’re having a hard time breaking down your food and find that you’re experiencing an upset stomach after eating, and you’re looking for a natural digestive enzyme supplement that’s comprised of natural, proven ingredients. In that case, this is an excellent choice. For your peace of mind, it’s backed by a 90-day money-back guarantee, too!
Digestive Science Enzyme Renewal
A specially formulated supplement to minimize gas, bloating, constipation, and diarrhea while reducing inflammation, Digestive Enzyme Renewal is another high-quality formula. It’s also purported to reduce abdominal pain while boosting the absorption of nutrients.
Enzyme Renewal by Digestive Science is also said to help reduce the development of sore throat, hiccups, wheezing, coughing, and even sleep disturbances. With a 67-day money-back guarantee, and several significant discounts that can be found online, it’s not only affordably priced, but if you’re unhappy with it for any reason, you can request a full refund.
Amy Myers MD Complete Enzymes
Made by Amy Myers, MD, a medical doctor and the manufacturer of various health supplements, Complete Enzymes is designed to strengthen digestive health and nutrient absorption. When taken daily, this supplement is purported to help your body repair the intestines and react to inflammation, and those are just some of the benefits it’s said to offer.
Dr. Amy Myers has years of experience in the medical field and fully comprehends how crucial digestive enzymes are for health, which is why she’s made this supplement. It’s recommended for those with food sensitivities, issues with absorption, individuals who struggle with gluten, and those who just want to support the health of their gut and reduce the risk of inflammation. Complete with transparent labeling regarding the ingredients and the dosages and backed by a 90-day money-back guarantee, Complete Enzymes is one of the best digestive enzyme supplements on the market.
This digestive enzyme supplement is marketed to those looking to lose weight. It’s formulated to address the root cause of obesity, which includes digestive enzyme imbalances. Not only does AlphaZym Plus contain a variety of ingredients that are proven to aid in digestion, such as acai berry fruit extract, psyllium powder, inulin, slippery elm bark, chlorella, and aloe powder. These ingredients help the body push out waste and support detoxification. Some of these ingredients even help to prevent inflammation.
Though some of the benefits that this supplement advertises seem too good to be true, AlphaZym Plus is still highly effective and widely used and may help you lose weight in various ways, thanks to the clinical doses of proven ingredients that it contains.
EnzyMedica Digest Gold + Probiotics
Another prevalent digestive enzyme aid, EnzyMedica Digest Gold + Probiotics, helps speed up digestion, increases energy levels, minimizes gas, bloating, and indigestion, and provides a variety of other health benefits.
This supplement is a 2-in-1 digestive health formula. It breaks down protein, fat, fiber, and carbs via digestive enzymes that have been proven to be highly effective. This formula is also the only option on our list that features TherActive probiotics, which are known to help further the digestive health benefits that it offers. With each serving, you will receive 1.5 billion active cultures, as well as a multitude of high-quality ingredients. Digest Gold is well priced, easy to use, and appears to yield highly effective results.
SynoGut Dietary Supplement
SynoGut is a dietary supplement developed by Samuel Bart, a natural health specialist who has nearly 50 years of experience under his belt. Because Bart knows how vital digestive enzymes are for overall health and well-being, he wanted to develop a highly effective supplement made of all-natural ingredients; that’s just what he did with SynoGut!
Examples of some of the all-natural, proven, and highly-effective ingredients that SynoGut contains include the following:
- Bentonite clay
- Black walnut
- Aloe vera
- Apple pectin
While other digestive enzyme supplements are geared solely on enzymes, SynoGut serves up healthy doses of fiber, probiotics, prebiotics, and more! It’s advertised to offer hyperbolic health benefits, and it’s backed by a full 90-day money-back guarantee, too!
Gut Garden Digestive Enzymes with Betaine HCL and Pepsin
Digestive Enzymes by Gut Garden is a digestive health supplement that features high-quality ingredients and offers a fantastic value. This formula features betaine, bromelain, pepsin, papain, and even ox bile extract. All elements proved to support various health and wellness benefits.
By taking Digestive Enzymes daily, the manufacturer purports that you can successfully optimize digestion, restore healthy stomach acid balances, and ease discomfort in the stomach after eating. Rather than just providing you with a hefty dose of digestive enzymes, this supplement offers a variety of methods of action that can further support health and well-being.
While Gut Garden may not be as recognizable as other manufacturers featured on our list, their Digestive Enzymes supplement is quickly growing in popularity. It has become one of the company’s fastest-growing options.
Thorne Research Bio-Gest Digestive Enzymes
Another premium-quality digestive enzyme supplement that is also very affordably priced, Bio-Get by Thorne, is not only practical, but it’s also one of the best-valued formulas on our list.
According to the manufacturer, by taking Bio-Gest daily, you will digest fats, proteins, and carbs a whole lot better. It uses pepsin, HC1, ox bile extract, and pancreatin, which the body’s enzymes need to support proper digestion. It can become harder to digest food as you age; however, you can maintain good digestion with the Bio-Gest supplement.
Of all the supplements included on our list, Bio-Gest is one of the few specially formulated to target insufficient stomach acid secretions. Some individuals don’t secrete appropriate amounts of stomach acid for various reasons, such as gallbladder removal. Thorne, the makers of Bio-Gest, is committed to solving issues with digestive enzymes with a high-quality formula.
Global Healing VeganZyme Advanced Enzyme Blend
Another full spectrum blend of enzymes proven to support digestion and strengthen immunity is VeganZyme Advanced Enzyme Blend by Global Healing. It is a vegan-friendly GMO-free formula that is highly effective and provides many benefits.
According to the manufacturer, by taking this supplement daily, you can nourish your body with the enzymes needed to support optimal digestion while strengthening the immune system and supporting overall health and well-being. It does this with ingredients that have been sourced from plants and that have been proven to work. It’s completely free of toxic GMOs, and it’s vegan-friendly, too. As if those benefits aren’t enough, VeganZyme is also backed by a 365-day money-back guarantee. If you aren’t happy with the supplement for any reason within one year of purchasing, you can contact the manufacturer, and they will issue you a full refund.
Overview of Our Top Digestive Enzyme Supplements for 2022
Now that you’ve read through the detailed reviews of our top picks for the best digestive enzyme supplements, let’s look at a quick roundup of the supplements that are featured on our list.
- 1MD EnzymeMD: The best digestive enzyme supplement, offering broad-spectrum digestion support.
- EnzyBurn: The top-rated supplement for weight loss and fat burning, thanks to the unique fat-metabolizing enzymes that it contains.
- Live Conscious DigestWell: A fast-acting, broad-spectrum enzyme, probiotic, and plant-based formula eases digestive upset and improves nutrition absorption.
- BiOptimzers MassZymes: The best full-spectrum digestive enzymes support optimal absorption and digestion.
- BiOptimzers HCL Breakthrough: A 100 percent plant-based betaine hydrochloride and a full-spectrum enzyme blend that promotes healthy levels of stomach acids
- Onnit DigesTech: Highly trusted natural formulation of digestive enzymes that have been proven to aid in the digestion of proteins, carbs, and fats
- Onnit Total Gut Health. All-in-one digestive enzymes, probiotics, and prebiotics, as well as betaine HCI.
- Organixx Enzyme 17: Premium-quality, all-natural digestive health aide contains 17 essential natural enzymes that aid in the digestion of fat, carbs, and proteins.
- NSP Nutrition Digestive Enzymes: An ultra-blend of enzymes, as well as Makzyme Pro, helps to support digestive health, improve absorption of nutrients, and improve food breakdown.
- Vital Plan Active Enzymes: A plant-based digestive enzyme supplement formulated by a doctor and is designed to support the function of the gastrointestinal tract.
- Natural Health Source Digestive Enzyme Renewal: Supports pre-digestion of food and enables the gut to do its job a lot easier, so you experience less abdominal pain.
- Complete Enzymes by Amy Myers, MD: Made by a medical doctor and proven to support optimal nutrient digestion
- AlphaZym Plus: A trendy digestive enzyme supplement that aids in fat burning
- EnzyMedica Digest Gold: Made with advanced enzymes and TherActive Probiotics that help to break down fiber, fats, proteins, and carbs
- SynoGut: Supports the health of the digestive system with entirely natural ingredients and a proprietary blend of Glucomannan.
- Gut Garden Digestive Enzymes: Made to optimize gut health with highly potent herbal enzymes and Betaine HCL and Pepsin.
- Thorne Bio-Gest: Top-rated digestive health supplement on Amazon.
- VeganZyme: A highly advanced, full-spectrum blend of 24 highly powerful, GMO-free, vegan-friendly enzymes.
How We Selected the Top Digestive Health Supplements for 2022
Every manufacturer of digestive health enzyme supplements claims that they can improve digestive health in many ways; however, the truth is, some don’t live up to those claims. When selecting the supplements on our list, our team spoke with the makers, assessed laboratory reports, and even tested them out themselves (when possible). Based on the information they collected and using the following factors, we selected the best supplements currently available on the market.
Enzymes Proven to Work
We chose those made with digestive enzymes proven to work when selecting supplements.
Dosages Clinically Proven to Work
We also preferred supplements that contained dosages that were clinically proven to work.
The longer they’re in your digestive tract, the better digestive health enzymes work. That’s why we preferred supplements that remained in the system for a more extended period.
The Benefits Advertised
Though some manufacturers claim that their products can help you lose substantial amounts of weight in short periods without having to diet or exercise, the fact is, that isn’t true. Our team was wary of supplements that claimed they could provide profound results and instead chose options that advertised real benefits.
Amount of Enzymes
The best digestive enzyme supplements are comprised of a variety of enzymes, allowing them to break down a variety of foods. That’s why we selected formulas that contain several enzymes rather than those that feature only one or two enzymes.
Value and Cost
Another important factor we considered was the value and the cost of the supplements. Some shoppers want to spend less than $30, while others don’t mind paying $100 or more. Though we weren’t picky about particular budgets, we did give preference to supplements that offered great value at every price range.
Reputation and History of the Manufacturer
The manufacturers of some supplements are well-established and have outstanding reputations, while others are newly established and haven’t made a name for themselves yet. When selecting the supplements for our list, we gave preference to formulas that manufacturers made in the former group.
A manufacturer that stands behind the products says a lot about the quality. That’s why we were keen on choosing formulas backed by money-back or satisfaction guarantees.
Lastly, we preferred supplements that contained additional ingredients that complement the digestive enzymes, such as probiotics and prebiotics.
Signs You Should Consider Taking a Digestive Enzyme Supplement
So, how do you know if you should consider taking a digestive enzyme supplement? Here are some of the most common signs that indicate you have an imbalance in your enzyme counts and may benefit from taking a supplement:
- Constipation and diarrhea
- Weight loss or weight gain, unexpectedly
- Upset stomach after eating
- Sharp stomach pain
- Visible bits of undigested food, fats, or oils in your stool
In addition to the above, if you have a severe case of digestive enzyme imbalance, you may even become malnourished. If you’re experiencing any of these symptoms, speak with your doctor to determine if taking a digestive enzyme supplement would benefit you.
Breakdown of Digestive Enzymes
Your body produces and uses digestive enzymes to target specific foods and components of those foods. If you are having a hard time digesting carbs, for instance, you may want to take a protease enzyme supplement, while if you are feeling bloated, a full spectrum digestive enzyme supplement may be in your best interest.
Here’s a look at some of the most common digestive enzymes and what they target:
- Lipase: fats and oils
- Cellulase: fiber-rich, cellulose plants
- Protease: proteins
- Alpha galactosidase: starches
- Peptidase: proteins found in gluten and casein
- Pectinase: pectin in fruits
- Amylase: starches
- Lactase: lactose sugars (dairy)
- Glucoamylase: maltose sugars
Frequently Asked Questions About Digestive Enzyme Supplements
We’re sure that you have some questions about digestive enzyme supplements, as so many people do. Below, we’ve included the answers to some of the most frequently asked questions that we receive about these supplements.
Q: When should I take digestive enzyme supplements?
A: You should take a supplement for about 15 to 30 minutes before eating.
Q: How do you take these supplements?
A: Most supplements are made in capsules or powders. If a pill, swallow it with water before eating. If a powder, mix with water and drink before eating.
Q: Do digestive enzyme supplements have side effects?
A: While they are rare, digestive enzyme supplements can cause adverse effects. These effects can include:
- Abdominal pain
Q: How long do digestive enzymes work?
A: They usually work for 45 to 60 minutes after taking, on average.
Q: What do these supplements do?
A: They can help reduce upset stomachs, support weight loss, increase the absorption of vital nutrients, and improve your overall health and well-being.
Q: Where are digestive enzymes produced in the body?
A: The body naturally secretes digestive enzymes from the mouth, the stomach, and the intestines; however, the vast majority are produced by the pancreas.
Q; What are the benefits of digestive enzyme supplements?
A: These supplements can provide several benefits, including:
- Ease digestive upset, such as gas, bloating, indigestion, and heartburn
- Minimize digestive distress
- Improve bowel function and the microbiome to support a healthy intestinal environment
Q: Where do the digestive enzymes in supplements come from?
A: The enzymes used in supplements come from plants.
Q: Do digestive enzyme supplements work?
A: Several studies have found that they can offer profound benefits for many who take them; however, not all who use these supplements will see the results they are looking for.
Q: Are these supplements safe?
A: Generally speaking, for healthy adults yet, digestive enzyme supplements are safe when taken in regular doses. With that said, you should talk with your health care professional before taking a supplement, especially if you have a medical condition or you are taking medication.
The Best Digestive Enzymes for 2022 Final Thoughts
Digestive enzymes have become increasingly popular in recent years. That’s because people are becoming increasingly aware of the importance of good digestion; plus, so many are developing food intolerances due to poor diets and unhealthy GMO foods. If you have digestion issues or want to improve your overall health and well-being, taking a digestive enzyme supplement may be beneficial. The products featured on our list are the best of the best. They contain high-quality ingredients, clinically proven dosages and are backed by dozens of positive customer reviews, and those are just some of the benefits.
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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.