Home Natural Supplements Best Berberine Supplements (2021) Review the Top Picks to Buy

Best Berberine Supplements (2021) Review the Top Picks to Buy


A few years ago, Berberine was virtually unknown.

Today, it’s one of the most popular supplement ingredients on the planet.

You can find Berberine in weight loss formulas, metabolism boosters, and blood sugar support supplements. It’s trendy for weight loss, and some studies show Berberine could significantly increase fat burning.

However, there are so many berberine supplements that it’s tough to know which one is right for you. We performed hundreds of hours of research to find the best berberine supplement. After deliberation, analysis, and comparison, we identified the best berberine supplements of 2021.

The Best Berberine Supplements in 2021

Any berberine supplement can claim to accelerate weight loss results. However, only the top-ranked berberine supplements truly work.

After extensive debate, here’s how our editorial team ranked the best berberine supplements available today.

  • Exipure
  • EzyAbsorb Insulin Herb Berberine
  • CarboFix
  • Nuzena
  • Alive By Science Powdered Liposomal Berberine
  • 1MD GlucoseMD
  • EnzyMedica Berberine
  • Longevity Activator
  • Blood Sugar Premier
  • Vital Plan Gut Balance
  • Double Wood Supplements
  • Thorne
  • aSquared
  • LiftMode Berberine
  • Vivo Tonic
  • Claritox Pro
  • LiGenics



Launched in 2021, Exipure has quickly become one of the internet’s trendiest diet pills. Described as “the tropical secret for healthy weight loss, Exipure uses Berberine and other ingredients to support weight loss in various ways.

According to the makers of Exipure, weight gain is unrelated to diet or exercise habits. Instead, it’s related to brown adipose tissue levels within your body. Some people have high levels of brown adipose tissue, while others do not.

By taking two capsules of Exipure daily, you can purportedly use Berberine and seven other nutrients and plants to raise brown adipose tissue in your body. Exipure contains unique ingredients like propolis (from bees), oleuropein (from olive leaf), and quercetin (an antioxidant).

EzyAbsorb Insulin Herb Berberine


EzyAbsorb Insulin Herb Berberine is a high-quality berberine supplement that combines the proven effectiveness of Berberine with other popular ingredients like milk thistle and silymarin.

By taking Insulin Herb Berberine daily, you can purportedly take advantage of the “Ayurvedic miracle plant” to support blood sugar and cholesterol levels. Multiple studies have verified the ability of Berberine to maintain healthy blood sugar and cholesterol levels. With EzyAbsorb Insulin Herb Berberine, you could enjoy anti-hyperglycemic benefits to support overall cardiovascular health.

Another advantage of Insulin Herb Berberine is that it uses organic Berberine from the tree bark of Phellodendron amurense. Each capsule contains 500mg of pure berberine extract along with other active ingredients.



CarboFix is a weight loss supplement that claims to turn on your metabolism in three seconds using the power of Berberine and other active ingredients. Based on a formula from a village in Ecuador, CarboFix claims to make weight loss easy and instant, allowing you to lose a significant amount of weight quickly.

According to reports on the official CarboFix website, some people lose 2lbs per day when taking the formula. Others claim to have rapidly lost weight with limited diet and exercise required – even after being overweight for most of their lives.

Inside each capsule of CarboFix, you’ll find ingredients like Berberine, cinnamon, alpha-lipoic acid, chromium, and benfotiamine. These are some of the most popular and proven diabetes-fighting ingredients available. They help activate AMPk. According to the manufacturer of CarboFix, most people see noticeable results within just 72 hours of taking the supplement, making it one of the fastest-acting berberine supplements on our list.

Nuzena Berberine Pure +


Nuzena Berberine Pure + is one of the top-rated berberine supplements available today. Featuring 1,200mg of berberine extract per serving, it’s also one of the highest-powered supplements on our list.

Plus, at just $40, Nuzena Berberine Pure + offers surprisingly good value. Taking two capsules of the supplement daily can purportedly support a healthy metabolism, support healthy blood sugar levels, and support healthy cholesterol, among other benefits.

If you only want Berberine with no filler ingredients, then Nuzena Berberine Pure + is the best option on our list. There are no complimentary ingredients in Nuzena’s formula, and there are no active ingredients: you get 1,200mg of Berberine per serving, and that’s it. The formula is designed to support cholesterol, metabolism, and blood sugar, among other benefits.

Alive By Science LIPO Berberine (Powdered Liposomal Berberine)


The newly launched Powdered Liposomal Berberine from Alive By Science is one of the most unique formulations on this list and is easily up for consideration as the best berberine supplement to buy. With a highly concentrated 150 mg liposomal Berberine per pill, every capsule is 3rd party tested for purity and safety. The LIPO Berberine supplement utilizes a sustained-released liposomal delivery system that supports superior absorption and helps aid in the activation of the important metabolism regulating enzyme called AMPK.

Hailed as the new gold standard in berberine supplementation, the Alive By Science LIPO Berberine formula is said to, “maximum nutrient absorption throughout the body and is clinically proven to enhance the bioavailability up to 6x more than liquid liposome formulations.” Priced at a competitive and overall affordable price given the quality and advanced delivery system for optimal results, LIPO Berberine is only $49.95 per bottle and is a hard one to pass on if none of the above berberine supplements spoke loudly enough.

1MD GlucoseMD


1MD GlucoseMD, like other top-rated options on our list, is one of the few berberine supplements created by a medical doctor – not a marketing team. GlucoseMD was developed and recommended by Dr. Heather Shenkman, who added seven powerful ingredients to the formula for their ability to work synergistically to promote better sugar metabolism.

By taking GlucoseMD daily, people with diabetes can purportedly support blood sugar in multiple ways. GlucoseMD uses a blend of numerous blood sugar supporting ingredients proven to work, including cinnamon extract (in the form of CinSulin), Berberine, Gymnema Sylvestre, and chromium.

According to 1MD, people who take GlucoseMD daily could promote cardiovascular health, healthy blood sugar metabolism and absorption, and other benefits – all within just two weeks of taking the supplement for the first time. Although it’s priced slightly higher than competing products, it offers good value compared to other doctor-formulated blends.

EnzyMedica Berberine


EnzyMedica Berberine is a popular and well-rated berberine supplement designed to help maintain healthy blood sugar metabolism and immune support function, among other benefits. Priced at just $27.49 per bottle, it’s also one of the best-value options on our list.

Made in a targeted release capsule, EnzyMedica Berberine is also one of the few on our list to promote a healthy microbiome. Most berberine supplements claim to support blood sugar and immunity, but EnzyMedica specifically claims their formula helps with your gut microbiome.

EnzyMedica Berberine, like other top-rated berberine supplements on our list, is GMO-free, gluten-free, dairy-free, vegan, and soy-free.

Longevity Activator


Longevity Activator is an anti-aging formula formulated by a doctor as some of the best berberine supplements on our list. Dr. Ryan Shelton of Zenith Labs created Longevity Activator with Berberine and other ingredients to support anti-aging benefits.

By taking Longevity Activator daily, you can purportedly promote memory and brain health, fortify yourself against joint discomfort, and support energy and mood, among other benefits. Berberine is one of over a dozen ingredients within Longevity Activator. In addition to 25mg of Berberine, the supplement contains taurine, astragalus root, L-carnosine, ginger, and other proven ingredients.

Longevity Activator is also one of the few on our list, backed by a six-month guarantee. While others have a 30 or 60-day money-back guarantee, Zenith Labs gives you 180 full days to try the formula for yourself to see if you like it.

Blood Sugar Premier


Blood Sugar Premier is the second Zenith Labs supplement on our list. Priced at $49 per bottle, Premier is a blood sugar support supplement designed to help with body fat, blood sugar, and healthy insulin levels. While Longevity Activator (the other Zenith Labs supplement on our list) focused on anti-aging, Blood Sugar Premier focuses on helping people with diabetes manage blood sugar.

Dr. Ryan Shelton of Zenith Labs formulated Blood Sugar Premier. By taking it daily, people with diabetes can purportedly support healthy blood sugar (that’s already in a normal range), have more freedom to enjoy their favorite foods (even sugary desserts), and avoid blood sugar spikes, among other benefits, according to Zenith Labs.

To deliver these benefits, Zenith Labs has added three of the most proven ingredients to Blood Sugar Premier, including Berberine, turmeric root, and piperine. These three ingredients could support blood sugar in various ways, making it easier for people with diabetes to avoid wild swings between meals.

Vital Plan Gut Balance


Vital Plan Gut Balance is the only supplement on our list explicitly designed for gut health. While other berberine supplements target blood sugar and weight loss, Gut Balance targets your gastrointestinal tract, liver, and gut flora.

By taking two capsules of Gut Balance daily, you can purportedly promote digestion, detoxification, and normal bowel function, among other benefits. You can also support healthy gut flora composition, help maintain blood sugar levels with a normal range, and support the optimal liver, gallbladder, and pancreatic function, among other effects.

Plus, each bottle contains 60 servings, more than the 30 servings found in other berberine supplements listed here. Berberine is one of three listed ingredients in Gut Balance: each three capsule serving contains 400mg of Berberine, 300mg of dandelion extract, and 500mg of slippery elm bark.

Double Wood Supplements


Double Wood Supplements makes a popular berberine supplement with 500mg of Berberine in each capsule. Plus, there is a 60 capsules bottle, and it’s priced at just $20, making it the best-value berberine supplement on our list.

While other supplements contain a fraction of Berberine at a higher price, Double Wood Supplements uses a soy-free, gluten-free, non-GMO, vegan formula to give you a potent daily dose of Berberine.

According to Double Wood Supplements, the formula will support cardiovascular function, support mental health, and promote healthy cholesterol, among other benefits.

Thorne Berberine


Thorne Research Berberine is one of the higher-quality berberine supplements on our list. Priced at $35 for 60 servings, it’s also one of the more affordable options. Plus, backed by an average rating of 4.6 stars with 1,700+ reviews on Amazon, it’s also one of the best-rated options available.

Thorne Research Berberine contains just one active ingredient in each capsule: 500mg of Berberine. You take two pills daily to support optimal wellness, weight, blood sugar, and bacteria.

While other berberine supplements dazzle you with claims of how Berberine will transform your body, Thorne takes a different approach, giving you a strong dose of Berberine while letting you enjoy whatever benefits you like. It’s not strictly a weight loss, inflammation, or blood sugar aid; it’s a combination of everything.

aSquared Nutrition Berberine


aSquared Nutrition is a long-running and well-established supplement company, and their berberine supplement is one of the best in the industry. Featuring 1,000mg of Berberine per serving and 180 capsules per bottle, aSquared’s Berberine 1,000mg is one of the best-value and most popular options on our list.

Each capsule contains 500mg of Berberine, giving you a 90 day supply of Berberine in each bottle for around $35. According to aSquared, this Berberine can support cardiovascular health, inflammation, and overall wellness, among other benefits.

aSquared Nutrition is an AMPK activator and anti-aging solution linked to cellular energy and weight loss. Studies have shown that Berberine activates AMP-activated protein kinase (AMPK), making it easier to lose weight.

LiftMode Berberine


LiftMode Berberine is the only berberine supplement on our list that comes in a powder instead of a capsule or tablet. It’s a 98% pure berberine powder designed to promote heart health and metabolism while reducing inflammation.

Each jar contains ten servings of formula. But with 5g of Berberine per serving, it’s one of the largest serving sizes on our list (other capsulated berberine supplements typically contain around 500mg of Berberine per capsule).

By taking LiftMode Berberine daily, you can enjoy powerful antioxidant and anti-inflammatory effects with a 100% vegan and vegetarian-friendly formula. And, at under $10 per jar, it’s also one of the cheapest berberine supplements on our list.

Vivo Tonic


Vivo Tonic isn’t the best-known berberine supplement on our list. However, it makes up for the lack of name-brand recognition with an 11-in-1 blood sugar support formula that helps your body maintain healthy blood sugar levels using high-quality ingredients.

According to the makers of Vivo Tonic, they developed the recipe based on an ancient formula used by monks in Kathmandu to manage blood sugar. These monks took specific vitamins and nutrients to support healthy blood sugar levels and maintain overall health.

Today, Vivo Tonic uses a blend of proven health-supporting ingredients, including Berberine, banaba leaf, silymarin, ginseng, resveratrol, and zinc, among others. At $79 per bottle, it’s one of the costlier berberine supplements on our list, although a 60-day money-back guarantee backs it.

Claritox Pro


Claritox Pro is a plant-based organic supplement containing Berberine, green tea extract, chromium, zinc, milk thistle, resveratrol, and other proven ingredients.

By taking Claritox Pro daily, you can purportedly “improve the general nature of your wellbeing,” according to the manufacturer, which is an effect we don’t see advertised with other formulas listed here. The supplement can also purportedly “upgrade mind usefulness,” “actuate your digestion,” and “lessen the danger of getting any sort of illness,” among other uniquely-worded benefits.

To learn more about Claritox Pro and how the supplement works, visit the official website today at ClaritoxPro.com.



LiGenics is the world’s first 100% natural solution addressing the four pillars of weight loss. According to the makers of LiGenics, the formula targets adipogenesis, insulin balance, stable metabolic rate, and hormones, making it more effective for weight loss than competing supplements sold online today.

Priced at $59 per bottle, LiGenics is more expensive than the competing options listed here. However, the supplement claims some people “lose fat too fast” when taking the formula, forcing them to cut the dose in half – that’s how powerful LiGenics can be for rapid weight loss.

Plus, each LiGenics capsule is manufactured in the United States in a single, certified facility. And, in addition to rapid weight loss, the formula can purportedly give you smoother joints, silkier hair, stronger nails, and glowing skin, among other benefits – effects we don’t see advertised with other berberine supplements on our list.

How We Ranked The Best Berberine Supplements

All berberine supplements claim to support blood sugar and weight loss. Unfortunately, most of them don’t work. To separate the best and worst berberine supplements, we used the following metrics.

Berberine Dosage

Berberine is rarely found in supplements on its own. Instead, it’s typically found as part of a blend. You might find it in a blood sugar support formula, for example, or in a weight loss formula with caffeine and other weight loss boosters. Nevertheless, we considered berberine dosage heavily in our rankings. We preferred supplements with a potent, clinically-proven dose of Berberine.

Advertised Benefits

Berberine is not a miracle drug. In fact, per FDA regulations, supplement companies cannot advertise Berberine as a treatment, cure, or preventative measure for any disease. We were wary of supplement companies that claimed Berberine could solve all your problems.

Realistic Weight Loss Goals

Some berberine supplement companies claim their products can help you lose 30lbs in a week. Others claim to help you lose weight with zero dieting or exercising. Neither of these claims is realistic. We preferred berberine supplements with actual weight loss goals instead of exaggerated claims.

Realistic Blood Sugar & Diabetes Claims

Berberine won’t cure diabetes. There’s no known cure for diabetes. Berberine may help support healthy blood sugar in conjunction with good dieting and exercise. However, it won’t eliminate diabetes from your body, nor will it allow you to stop taking insulin overnight. You should be wary of berberine supplement companies that advertise and dishonest health benefits to people with diabetes. Berberine can support symptoms of diabetes – but it won’t eliminate or cure diabetes.

Manufacturer Reputation & Track Record

Some berberine supplement companies have been producing high-quality supplements for decades. Others created a berberine supplement because they saw it was trendy and wanted to sell many products online. We preferred berberine supplement companies with a long and proven track record for creating high-quality berberine formulas.

Formulated by Doctors or Approved by Medical Advisory Board

You don’t need to be a doctor to launch a supplement, but it certainly gives your formula an added degree of legitimacy. We preferred berberine supplements that had been formulated by doctors or approved by a medical advisory board.

Complementary Ingredients

Most berberine supplements contain more than just Berberine. Berberine weight loss supplements, for example, may contain appetite suppressants, caffeine, thermogenic, and other ingredients linked to weight loss. Berberine diabetes supplements, meanwhile, may include vitamins, minerals, and amino acids shown to support healthy blood sugar in people with diabetes. We primarily judged berberine supplements off of their berberine dosage, although we also considered complementary ingredients in our rankings.

Good Value at Any Price

Whether spending $10 or $100 on a berberine supplement, you should be able to get good value. We emphasized berberine supplements with substantial value at all price ranges. If you’re buying a cheap berberine supplement, you should still be able to get good-value ingredients. You should expect premium ingredients that justify the higher price tag if you purchase a premium berberine supplement. We considered price and overall value in our rankings to ensure customers were paying a fair price.

Money-back Guarantee & Refund Policy

Berberine won’t work for everyone. Sometimes, it won’t support blood sugar or help you lose weight. We want customers to have an excellent money-back guarantee or refund policy to back them up when this happens. We preferred berberine supplement companies backed by a 30, 60, or 90-day refund policy (or longer). It shows the manufacturer stands behind the formula.

Berberine Source

You can get Berberine from many plants like European barberry, goldenseal, goldthread, Oregon grape, Phellodendron amurense, and tree turmeric. We weren’t biased towards any specific source of Berberine. However, we did prefer natural and organic sources wherever possible.

Who Should Take Berberine?

People generally take Berberine for blood sugar and weight loss. However, anyone can take Berberine to support a range of benefits.

Some of the people who could benefit from Berberine include:

  • People with diabetes and anyone else with issues controlling blood sugar
  • People with high cholesterol
  • People with general cardiovascular issues
  • Anyone trying to lose weight
  • Someone trying to support a healthy lifestyle or support overall health and wellness
  • A good berberine supplement can help you enjoy all of these benefits.

How Does Berberine Work?

Berberine is a natural compound found in a range of plant species. Historically, it played an essential role in traditional Chinese medicine, Ayurvedic medicine, and other types of conventional medicine. It was used to treat infections, inflammatory conditions, and digestive issues.

Today, researchers believe berberine works by lowering cholesterol, triglycerides, and blood sugar levels. Early research suggests that Berberine can also lower blood sugar. These effects are significant because they’re all reversible risk factors for cardiovascular disease.

As The Memorial Sloan Kettering Cancer Center explains, one international panel of experts determined that Berberine may be helpful in patients with mild cases of high cholesterol who do not tolerate statin drugs. It could also be beneficial for patients with metabolic syndrome. If you have high cholesterol or high blood sugar but do not want to take medicines to manage your condition, or if you’re unable to take drugs, Berberine could be a good alternative.

What Does Berberine Do?

After you ingest Berberine, your body transports that Berberine into the bloodstream, then into your cells.

Once Berberine is inside your cells, it binds to several molecules, changing their function – similar to how pharmaceutical drugs and other supplements work.

At this point, Berberine begins to perform a range of biological mechanisms throughout the body. While other drugs and supplements target a specific area of your body – like the blood-brain barrier – berberine targets multiple areas of the body with diverse effects.

We do know, however, that Berberine activates an enzyme called AMPK (AMP-activated protein kinase) within your cells. Some supplements refer to this enzyme as a metabolic master switch. By activating this switch, you may be able to boost metabolism in every cell of your body, making it easier to lose weight.

Ultimately, Berberine has a diverse range of effects throughout the body, and we’re still learning more about what Berberine does and how it works.

Side Effects of Berberine

There are a few significant side effects of Berberine. Most healthy adults can take a regular dosage of Berberine without issue.

However, possible mild side effects associated with Berberine include:

  • Appetite loss
  • Upset stomach
  • Diarrhea
  • Constipation
  • Rash (when applying Berberine topically)

Aside from these mild side effects, Berberine is generally tolerated well.

Berberine Benefits: What Does Science Say?

Studies show that Berberine could help support several benefits throughout the body. Some studies have shown that Berberine could lower blood sugar, for example, while others have linked Berberine to actual weight loss results. We’ll summarize Berberine’s research below.

Berberine & Diabetes

Berberine has shown the most promise as a diabetes supplement. Multiple studies have shown that taking Berberine can lead to a significant drop in blood sugar levels.

For example, in this review study, researchers found multiple trials proving that Berberine can significantly reduce blood sugar in people with type 2 diabetes. Many type 2 diabetics struggle to manage their blood sugar levels after meals, and they take insulin and other medication to help manage their blood sugar. Berberine appears to help.

Similarly, this study found that Berberine had similar effectiveness to the popular diabetes drug metformin (Glucophage). Researchers gave Berberine or metformin to a group of diabetics, then observed similar benefits across both groups.

Another study analyzed the effects of giving 1,000mg of Berberine to 116 patients with diabetes. Researchers found that Berberine lowered fasting blood sugar by 20%, dropping it from 7.0 to 5.6 mmol/L (126 to 101 mg/dL), enough to change the rating from diabetic to normal levels.

Why does Berberine help with blood sugar and diabetes? Studies have suggested different mechanisms. Some studies have found that Berberine decreases insulin resistance, making it easier for insulin, your blood sugar-lowering hormone, to do its job. Other studies have suggested that Berberine reduces sugar production in the liver, helps break down sugars inside cells, or slows the breakdown of carbs in the gut, among other benefits.

Berberine & Weight Loss

Others take Berberine for weight loss. Multiple studies have shown that Berberine can help you lose weight when taken daily.

For example, researchers told participants to take 500mg of Berberine three times per day over 12 weeks in this study. This showed participants had lost around 5 pounds of weight, on average, and 3.6% of their body fat.

In another study, researchers analyzed the weight loss effects of Berberine on 37 men and women with diabetes. Researchers told participants to take 900mg of Berberine per day (3 doses of 300mg each). At the end of the three months, participants had lowered their body mass index (BMI) from 31.5 to 27.4, enough to drop them from obese to overweight. Participants also lost belly fat and improved health markers.

Why does Berberine help with weight loss? Researchers believe Berberine helps with weight loss by improving the function of fat-regulating hormones – including insulin, leptin, and adiponectin. These hormones can also control blood sugar and appetite, making it easier to avoid cravings. Other studies have suggested that Berberine helps with weight loss by inhibiting the growth of fat cells at the molecular level. Berberine may tell your body to stop storing fat. ;

Berberine & Heart Health

Berberine has been linked to a range of heart health benefits, including everything from lower cholesterol to a lower risk of heart disease.

In this review study, researchers found evidence showing that Berberine can lower cholesterol significantly. Specifically, researchers found that Berberine lowered total cholesterol, LDL cholesterol, blood triglycerides, and HDL cholesterol.

Another study found that Berberine lowered apolipoprotein by 13% to 15%. This protein is a significant risk factor for cardiovascular disease. Another study found that Berberine inhibited an enzyme called PCSK9, helping to remove LDL from the bloodstream.

One study even linked Berberine to a reduced risk of heart failure. Researchers gave Berberine to a group of patients with heart failure and found it reduced the risk of death and drastically improved symptoms.

Many people take Berberine daily to support cardiovascular health, cholesterol, and overall heart performance for all of these reasons.

Berberine & Other Benefits

Studies have linked Berberine to a range of other benefits.

In one study on rats, for example, researchers found that Berberine may help with depression. Another study reinforced this finding, suggesting that Berberine could demonstrate anti-depressant-like benefits. Researchers gave Berberine to mice and rats, then exposed them to stress tests. Researchers found that animals in the berberine group had lower depression markers than animals in the placebo group.

Some take Berberine for general inflammation and antioxidant effects. In this 2011 study, researchers found that Berberine inhibited inflammatory response and improved insulin resistance. In a separate study, researchers found that Berberine lowered cholesterol in mice with high levels of inflammation, suggesting that Berberine could help with inflammation and cholesterol.

Berberine is also known for its ability to target infections and illnesses. Studies show that Berberine may fight viruses, bacteria, fungi, parasites, and other harmful microorganisms. In this 2002 study, for example, researchers reviewed the evidence on Berberine and found it associated with antimicrobial activity. In a separate 2011 study on Berberine, researchers tested the effects of Berberine on the influenza virus and found Berberine positively interacted with the virus to neutralize specific effects.

Fatty liver disease affects millions of people. Some studies suggest Berberine could help with non-alcoholic fatty liver disease. In this study, for example, researchers found that Berberine reduced fat buildup in the liver, helping to protect you against NAFLD. Researchers found Berberine exhibited this effect through modulation of hepatic mRNA and lncRNA expression profiles, targeting two genes linked to fatty liver disease.

Some of the most exciting areas of research on Berberine are its anti-cancer effects. In one 2020 study, for example, researchers told a group of 900 patients in China to take 600mg of Berberine daily or a placebo after they had polyps removed during a colonoscopy. Most internal polyps are benign, but some can become cancerous. None of the patients developed cancer during the study. However, patients in the berberine group had fewer recurrent polyps than the placebo: 36% of patients in the berberine group developed recurrent polyps compared to 47% in the placebo group.

Berberine is a relatively new supplement ingredient that has not been studied extensively in humans, although early research on the benefits of Berberine is promising.

Plus, Berberine is backed by 400+ years of use in traditional Chinese and Ayurvedic medicine. As we learn more about Berberine and how it works, a growing number of people are using Berberine for diabetes, weight loss, heart health support, and other effects.

Recommended Dosage of Berberine

Most berberine studies use a dosage of 1,000mg to 2,000mg per day, often spread into 2 to 4 separate dosages.

The average dose of around Berberine is around 1,500mg per day.

A good berberine supplement has around 500mg of formula per serving. However, many of the top-ranked berberine supplements above have less Berberine because they’re part of a blend of multiple ingredients.

In this study on patients with diabetes, researchers found that taking 1g of Berberine per day lowered fasting blood sugar by 20%.

FAQs About Berberine

We’re berberine supplement experts. We get plenty of questions about Berberine and how it works. Here are our answers.

Q: What is Berberine?

A: Berberine is a natural chemical found in several plants. Studies show that Berberine could help with diabetes, weight loss, and inflammation, among other benefits.

Q: Is Berberine Safe?

A: Berberine appears to be safe for most healthy adults to take in standard dosages. However, you should talk to your doctor before taking Berberine if you have a health condition or are taking medication.

Q: What are the side effects of Berberine?

A: Berberine side effects are rare. However, some people experience upset stomachs and nausea when taking Berberine.

Q: Where does Berberine come from?

A: Berberine is a natural extract from several plants, including European barberry, goldenseal, goldthread, Phellodendron amurense, Oregon grape, and tree turmeric.

Q: How do I use berberine?

A: People generally use Berberine as an oral supplement: you swallow a capsule or tablet daily to enjoy the effects of Berberine. However, some people apply Berberine topically (directly to their skin).

Q: What does Berberine do?

A: Berberine is best-known for its effects on blood sugar and weight loss. Many people take Berberine daily to support healthy blood sugar or to help with weight loss. Berberine has also been linked to cholesterol, bacteria, digestive issues, and cardiovascular health, among other areas.

Q: What’s the best dose of Berberine?

A: The standard dose of Berberine is 1,000mg to 2,000mg per day, separated into 2 to 4 portions.

Q: When should I take Berberine?

A: You can take Berberine at any time of day. However, most experts recommend taking it with a meal or shortly after a meal to maximize the effects on blood glucose.

Q: How long do I need to take Berberine to enjoy benefits?

A: According to certain studies, Berberine can reduce fasting blood glucose in as little as two weeks. Usually, however, it takes 3 to 4 weeks to notice the effects of Berberine.

Q: Can I take Berberine with my statin medication? Will berberine interact with statin medication?

A: Yes (after receiving permission from your doctor), you should be able to take Berberine with your statin medication. Studies show that Berberine could improve the effectiveness of statins. The combination is safe and effective. However, you should talk to your doctor before taking Berberine with any other medication.

Q: Does Berberine help with diabetes?

A: Studies show that Berberine could lower blood sugar in people with diabetes. Multiple studies have linked blood sugar to better insulin response and better blood sugar support, among other similar benefits.

Q: Does berberine help with PCOS?

A: Berberine may help support women with PCOS by improving fertility, helping with weight loss, and lowering the risk of diabetes, cholesterol, and fatty liver disease, among other effects.

Q: Does Berberine help with weight loss?

A: Studies suggest that Berberine can help with weight loss. In multiple studies, researchers have observed significantly better berberine weight loss results compared to a placebo.

Q: How does Berberine help with weight loss?

A: Berberine may help you lose weight by targeting hormones linked to weight loss and appetite, including insulin and leptin.

Q: Does Berberine help with inflammation?

A: Berberine may help with inflammation. Studies show that Berberine could support healthy inflammation within your body in various ways.

Q: How much Berberine should I take?

A: The average berberine dose is around 1,500mg per day, split into three doses. However, you can take anywhere from 500mg to 2,000mg of Berberine daily to enjoy targeted benefits.

Q: What’s the best berberine supplement?

A: Exipure, EzyAbsorb Insulin Herb Berberine, CarboFix, and Nuzena are all good berberine supplements.

Q: What should I look for in a berberine supplement?

A: Look for a strong dose of pure Berberine from high-quality, natural sources and a reputable manufacturer.

The Best Berberine Supplements in 2021 Final Word

Berberine supplements have never been more popular. You have more berberine supplement options than ever. As a final glance at the best berberine supplements to buy in 2021, here is where to buy top-rated berberine extracts online:

  • Best berberine supplement for weight loss in 2021
EzyAbsorb Insulin Herb Berberine
  • Most potent berberine extract with Milk Thistle for blood sugar support
  • Most popular berberine supplement for burning fat fast
Nuzena Berberine Pure +
  • Most effective pure berberine supplement extract to buy
LIPO Berberine
  • Most innovative powdered liposomal berberine with highly concentrated and bioavailable berberine extract
1MD GlucoseMD
  • High quality berberine extract to target healthy glucose metabolism
EnzyMedica Berberine
  • Most affordable berberine HCI 95% (from berberis aristata bark and roots)
Longevity Activator
  • Trusted brand, doctor formulated berberine supplement with resveratrol
Blood Sugar Premier
  • Trusted brand, doctor formulated blood sugar supplement with berberine hydrochloride extract from barberry root
Vital Plan Gut Balance
  • Quality brand berberine supplement with Slippery Elm Bark and Dandelion extract for optimal gut health and function
Double Wood Supplements
  • Straight forward affordable berberine extract with 500mg per capsule
Thorne Berberine 500
  • Hard to top dosed berberine product from a reputable brand with 1 gram of extract per pill
aSquared Berberine
  • Amazon’s Choice for berberine supplements on Amazon.com with 1000mg per serving
LiftMode Berberine
  • Cheapest berberine powder extract from berberis aristata root bark with 98%+ purity
Vivo Tonic
  • 11-in-1 berberine-rich blood sugar support formula
Claritox Pro
  • Multi-ingredient formula features berberine for balancing glucose levels and preventative agent against more glucose
  • Metabolism booster supplement with berberine ingredient included

Fortunately, we’re here to help narrow your options. Check out any top-rated berberine supplements above to enjoy some of the best berberine supplements available for weight loss, diabetes, and other benefits.

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.


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